Jeff Carroll
Investigator
Jeff Carroll joined the institute in 2026 to lead a team focused on translational research efforts around Huntington’s Disease within the Brain Health Accelerator. He received both his BSc and PhD at the University of British Columbia, where he conducted work under the supervision of Michael Hayden. After a postdoc at Harvard Medical School with Marcy MacDonald’s lab at MGH, Jeff began an independent research lab at Western Washington University which later moved to the University of Washington. While a graduate student, Jeff co-founded HDBuzz.net, a unique online information platform where HD families can get updates about cutting edge HD Science in news stories written by HD researchers in plain language. Over his scientific career, Jeff has used mouse and cellular models with a goal of hastening the development of effective treatments for Huntington’s Disease. The lab has had a long-term interest in “huntingtin lowering” strategies, using diverse technologies to lower levels of the mutant gene product that is the unambiguous cause of every case of Huntington’s Disease.
research focus
Jeff’s area of expertise is in Huntington’s Disease and related repeat expansion disorders, with a particular focus on translational studies in mouse models in these diseases. He has carried out foundational work in the development of Antisense Oligonucleotides as a therapeutic option in Huntington’s Disease, other rare expansion disorders and nano-rare disorders. In parallel to this translational work, Jeff has conducted work into better understanding the pathogenic mechanisms of Huntington’s Disease, with a particular focus on understanding the origin of transcriptional dysregulation in vulnerable neurons.
