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Bio:
Nathan Gouwens joined the Allen Institute in 2014 as a scientist in the Modeling, Analysis, and Theory group. Now as an Assistant Investigator, he is currently involved with developing biophysically detailed simulations of individual neurons in the mouse visual cortex. These simulations are based on combined electrophysiological and morphological data with the goal of determining how biophysical mechanisms shape the processing of visual information in cortex. Before joining the Allen Institute, Nathan was a graduate student in the lab of Rachel Wilson at Harvard Medical School. His graduate research involved analyzing how electrical signals propagated in the early olfactory circuit in Drosophila through a combination of electrophysiological experiments and computational models. Nathan received his PhD in Neurobiology from Harvard University, an MPhil in Biological Sciences from the University of Cambridge, and a BA in Integrated Science and Biological Sciences at Northwestern University.
Research Focus:
Nathan Gouwens is studying how biophysical mechanisms influence the processing of visual information by cortical neurons through the development of detailed simulations. These biophysical models are based on electrophysiological measurements of intrinsic properties as well as detailed morphologies, which can also serve as building blocks for larger-scale network simulations. The aims are to integrate diverse data to reproduce experimentally-observed features of neuronal activity and to gain insights into how different biophysical mechanisms interplay to shape the role a neuron plays in visual circuits.
Expertise
Research Programs
PLoS biology
Jun 01, 2023
Michael Hawrylycz, Maryann E. Martone, Giorgio A. Ascoli, Jan G. Bjaalie, Hong-Wei Dong, Satrajit S. Ghosh, Jesse Gillis, Ronna Hertzano, David R. Haynor, Patrick R. Hof, Yongsoo Kim, Ed Lein, Yufeng Liu, Jeremy A. Miller, Partha P. Mitra, Eran Mukamel, Lydia Ng, David Osumi-Sutherland, Hanchuan Peng, Patrick L. Ray, Raymond Sanchez, Aviv Regev, Alex Ropelewski, Richard H. Scheuermann, Shawn Zheng Kai Tan, Carol L. Thompson, Timothy Tickle, Hagen Tilgner, Merina Varghese, Brock Wester, Owen White, Hongkui Zeng, Brian Aevermann, David Allemang, Seth Ament, Thomas L. Athey, Cody Baker, Katherine S. Baker, Pamela M. Baker, Anita Bandrowski, Samik Banerjee, Prajal Bishwakarma, Ambrose Carr, Min Chen, Roni Choudhury, Jonah Cool, Heather Creasy, Florence D'Orazi, Kylee Degatano, Benjamin Dichter, Song-Lin Ding, Tim Dolbeare, Joseph R. Ecker, Rongxin Fang, Jean-Christophe Fillion-Robin, Timothy P. Fliss, James Gee, Tom Gillespie, Nathan Gouwens, Guo-Qiang Zhang, Yaroslav O. Halchenko, Nomi L. Harris, Brian R. Herb, Houri Hintiryan, Gregory Hood, Sam Horvath, Bingxing Huo, Dorota Jarecka, Shengdian Jiang, Farzaneh Khajouei, Elizabeth A. Kiernan, Huseyin Kir, Lauren Kruse, Changkyu Lee, Boudewijn Lelieveldt, Yang Li, Hanqing Liu, Lijuan Liu, Anup Markuhar, James Mathews, Kaylee L. Mathews, Chris Mezias, Michael I. Miller, Tyler Mollenkopf, Shoaib Mufti, Christopher J. Mungall, Joshua Orvis, Maja A. Puchades, Lei Qu, Joseph P. Receveur, Bing Ren, Nathan Sjoquist, Brian Staats, Daniel Tward, Cindy T. J. van Velthoven, Quanxin Wang, Fangming Xie, Hua Xu, Zizhen Yao, Zhixi Yun, Yun Renee Zhang, W. Jim Zheng, Brian Zingg
Cell
Jun 10, 2021
Zizhen Yao, Cindy T. J. van Velthoven, Thuc Nghi Nguyen, Jeff Goldy, Adriana E. Sedeno-Cortes, Fahimeh Baftizadeh, Darren Bertagnolli, Tamara Casper, Megan Chiang, Kirsten Crichton, Song-Lin Ding, Olivia Fong, Emma Garren, Alexandra Glandon, Nathan W. Gouwens, James Gray, Lucas T. Graybuck, Michael J. Hawrylycz, Daniel Hirschstein, Matthew Kroll, Kanan Lathia, Changkyu Lee, Boaz Levi, Delissa McMillen, Stephanie Mok, Thanh Pham, Qingzhong Ren, Christine Rimorin, Nadiya Shapovalova, Josef Sulc, Susan M. Sunkin, Michael Tieu, Amy Torkelson, Herman Tung, Katelyn Ward, Nick Dee, Kimberly A. Smith, Bosiljka Tasic, Hongkui Zeng
Nature Computational Science
Feb 01, 2021
Rohan Gala, Agata Budzillo, Fahimeh Baftizadeh, Jeremy Miller, Nathan Gouwens, Anton Arkhipov, Gabe Murphy, Bosiljka Tasic, Hongkui Zeng, Michael Hawrylycz, Uygar Sümbül
eLife
Dec 29, 2020
Jeremy A. Miller, Nathan W. Gouwens, Bosiljka Tasic, Forrest Collman, Cindy Tj van Velthoven, Trygve E. Bakken, Michael J. Hawrylycz, Hongkui Zeng, Ed S. Lein, Amy Bernard
PloS One
Jan 01, 2019
Natalie Weed, Trygve Bakken, Nile Graddis, Nathan Gouwens, Daniel Millman, Michael Hawrylycz, Jack Waters
Nature Communications
Feb 19, 2018
Corinne Teeter, Ramakrishnan Iyer, Vilas Menon, Nathan Gouwens, David Feng, Jim Berg, Aaron Szafer, Nicholas Cain, Hongkui Zeng, Michael Hawrylycz, Christof Koch, Stefan Mihalas