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Charles Cobbs

Swedish Neuroscience Institute

Dr. Cobbs is the Director of the Ivy Center for Advanced Brain Tumor Treatment at Swedish Neuroscience Institute in Seattle. He is an authority in the area of glioblastoma surgery and research. He first hypothesized that malignant gliomas and other tumors may be associated with chronic viral infection with human cytomegalovirus (CMV), and he published the first evidence that CMV is associated with glioblastoma. His group has subsequently found evidence of cytomegalovirus infection in other tumor types and evidence that the CMV receptor is a major receptor tyrosine kinase involved in tumor growth. These findings have led other researchers to explore treating these tumors with antiviral drugs and tumor vaccines against the CMV pp65 protein. Preliminary studies demonstrate unexpected prolonged survival in these glioblastoma patients.Dr. Cobbs received his undergraduate degree from Princeton University and his medical degree from the University of Alabama at Birmingham (UAB). He completed a residency in Neurological Surgery at the University of California, San Francisco (UCSF), where he also completed a fellowship in molecular neuro-oncology. Dr. Cobbs has previously been a principal investigator on NIH R01 grants, Special Project in Oncology Research (NCI SPORE) grants at UAB and UCSF, as well as an editor at Journal of Neuro Oncology and other journals. He has been a member of the NCI SPORE and PO1 brain tumor study sections. His laboratory group published a new molecular classification of glioblastoma in conjunction with the Allen Brain Institute in the journal Science.

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featured publications

publication / 2023
Signature morphoelectric properties of diverse GABAergic interneurons in the human neocortex
Science (New York, N.Y.)
publication / 2023
Interindividual variation in human cortical cell type abundance and expression
Science (New York, N.Y.)
publication / 2023
Morphoelectric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex
Science (New York, N.Y.)
publication / 2023
Target cell-specific synaptic dynamics of excitatory to inhibitory neuron connections in supragranular layers of human neocortex
eLife
publication / 2021
Human neocortical expansion involves glutamatergic neuron diversification
Nature
publication / 2021
Signature morpho-electric, transcriptomic, and dendritic properties of human layer 5 neocortical pyramidal neurons
Neuron
publication / 2021
Functional enhancer elements drive subclass-selective expression from mouse to primate neocortex
Cell Reports
publication / 2020
Transcriptomic evidence that von Economo neurons are regionally specialized extratelencephalic-projecting excitatory neurons
Nature Communications
publication / 2019
Conserved cell types with divergent features in human versus mouse cortex
Nature
publication / 2018
h-Channels Contribute to Divergent Intrinsic Membrane Properties of Supragranular Pyramidal Neurons in Human versus Mouse Cerebral Cortex
Neuron
publication / 2018
Distinctive Structural and Molecular Features of Myelinated Inhibitory Axons in Human Neocortex
eNeuro
publication / 2018
Sparse recurrent excitatory connectivity in the microcircuit of the adult mouse and human cortex
eLife
publication / 2018
A robust ex vivo experimental platform for molecular-genetic dissection of adult human neocortical cell types and circuits
Scientific Reports
publication / 2018
An anatomic transcriptional atlas of human glioblastoma
Science (New York, N.Y.)
publication / 2018
Preparation of Acute Brain Slices Using an Optimized N-Methyl-D-glucamine Protective Recovery Method
Journal of Visualized Experiments: JoVE
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