Request for Proposals: Epigenetics
November 28, 2016
Progress in the field of epigenetics has been hampered by a dearth of refined tools that would enable the measurement and manipulation of epigenetic phenomena over a wide range of spatial and temporal scales. Especially lacking are the tools that enable targeted cell type-specific manipulations and read-out at the single cell level and with high temporal resolution. Additionally, the field would benefit from the capability to visualize and follow such changes as they occur in real-time in vivo.
While single cell RNA-seq and DNA methylome sequencing technology has advanced, there has been less progress on measuring other molecular phenotypes at single cell resolution. In addition, methods to enable measurement of more than one of these phenotypes/properties at the same time in many single cells could be quite powerful for defining relationships between various types of cellular properties.
The Paul G. Allen Frontiers Group seeks to select investigators to pursue pioneering research that opens new directions and answers broad scientific questions. The most promising concepts will incorporate novel, creative, and ambitious approaches. For this reason, the program is especially interested in approaches that are unlikely to receive funding from traditional government sources.
We request letters of intent for proposals focusing on in vivo epigenetic editing, assessment and visualization technology development. There will be up to three awards made, and awards are anticipated to range from $1-1.5M in total funding over three years.