Jennifer Doudna research expanding the role of CRISPR published in Nature
September 26, 2016
Allen Distinguished Investigator Jennifer Doudna has published a landmark paper showing that the newly discovered CRISPR protein C2c2 has not one, but two distinct RNA cutting activities that in concert can be harnessed for robust RNA detection and degradation.
“This study expands our molecular understanding of C2c2 to guide RNA processing and provides the first application of this novel RNase,” said Doudna. “C2c2 is essentially a self-arming sentinel that attacks all RNAs upon detecting its target. This activity can be harnessed as an auto-amplifying detector that may be useful as a low-cost diagnostic.”