Information Storage and Retrieval in the Cardiac Extracellular Matrix

Jeffrey Holmes, M.D., Ph.D., will study how information is coded and stored in the extracellular matrix over the long term - many of these fibrous proteins accumulate changes that can persist in the matrix for years, unlike cells in the same region, which turn over much more frequently. Holmes and his team aim to understand how these proteins are deposited and modified, how frequently they turn over, how changes in the proteins influence neighboring cells and how aging influences the process overall. To do so, the team will use approaches and expertise from the fields of bioengineering, immunology, physiology and chemistry to capture an integrated picture of extracellular matrix dynamics in the heart. 

Affiliated Investigators

Jeffrey Holmes, M.D., Ph.D.

University of Virginia

Jeffrey Holmes is a Professor of Biomedical Engineering and Medicine and the founding Director of the Center for Engineering in Medicine at the University of Virginia. He obtained his B.S. in Biomedical Engineering from the Johns Hopkins University in 1989, his Ph.D. in Bioengineering from the University of California, San Diego in 1995, and his M.D. from the University of California, San Diego in 1998. His Cardiac Biomechanics Group studies the interactions between mechanics, function, and growth and remodeling in the heart, using a combination of computational and experimental models. His research has been funded by the National Institutes of Health, the National Science Foundation, the American Heart Association, the Whitaker Foundation, the Coulter Foundation, the Hartwell Foundation, and the Paul G. Allen Frontiers Group. Dr. Holmes was awarded the Y.C. Fung Young Investigator Award in 2005, an American Heart Association Established Investigator Award in 2006, and the Van C. Mow Medal in 2018. He is a Fellow of the American Heart Association, the American Institute for Medical and Biological Engineering (AIMBE), and the American Society of Mechanical Engineers.