Human age-equivalent directly induced neurons to study functional phenotypes of Alzheimer’s disease.

The goal of this research effort is to separate out the role of aging from the role of disease in Alzheimer’s disease progression. Dr. Gage will use cutting-edge cell culture methods capable of developing patient-specific neurons, as well as high-throughput RNA sequencing and bioinformatics analysis, to compare changes in gene expression due to age with changes specific to Alzheimer’s disease. Since both aging and disease impact neuron function, synapses and network function, this work will provide valuable insights into the role of normal aging in disease progression.

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Affiliated Investigators

Fred "Rusty" Gage, Ph.D.

Salk Institute for Biological Studies

Fred H. Gage, Ph.D., is a Professor in the Laboratory of Genetics at the Salk Institute. Dr.  Gage's  work  concentrates  on  the  adult  central  nervous  system  and  unexpected  plasticity  that remains   throughout   the   life   of   all   mammals.   In   addition, he   models   human neurological and psychiatric disease using human stem cells.  He also studies the genomic mosaicism that exists in the brain as a result of mobile elements that are active in the genome. Dr. Gage is a Fellow of the American Association for the Advancement of Science, a Member of the National Academy of Sciences and the Institute of Medicine, and American Philosophical Society, and a Member of the American Academy of Arts and Sciences. Dr. Gage has served as President of the Society for Neuroscience in 2002, and past President for the International Society for Stem Cell Research 2012.