Neuronal Maturation (2015)
Studying human brain cells is one of the most promising ways to better understand the function of the healthy brain as well as provide insight into the development of diseases like Alzheimer’s and Parkinson’s. However, growing those cells in vitro constitutes a major gap in our understanding. It typically takes more than a year to develop cells that come close to resembling fully mature neurons, and even then, yield is often low and full maturity has not been reached. The six projects chosen to receive ADI grants in this field of neuronal maturation all tackle one or more of these challenges in bold new ways, including using innovative technologies and novel points of view.
Affiliated Investigators
Affiliated Projects
Neuronal Maturation (2015)
“Flight Data” Recorder, Checkpoint Timing, Hodaptics, and Growth Cone Independence
Neuronal Maturation (2015)
Genome-Scale Technologies for Reverse-Engineering Transcriptional Logics Underlying Cell Fate Specification
Neuronal Maturation (2015)
Identifying and Inducing Hallmarks of Maturity in Human Neurons
Neuronal Maturation (2015)
Matching Regional Diversity with Function: Unique Astrocyte Signals Mature Regionally Matched Neurons
Neuronal Maturation (2015)
Transcriptomic and epigenetic acceleration of neuronal maturation and aging
Neuronal Maturation (2015)
Using miRNAs to Accelerate in vitro Circuit Maturation in 3D Neural Structures from ESCs