The Allen Institute for Cell Science will host booth #639 in the exhibitor hall where attendees can speak with our scientists and learn about our current and future work.
Be sure and check out the demonstration of our resources in virtual reality, and ask about our newest work in label-free imaging.
The Allen Institute for Cell Science – resources to empower your research
Date & Time: Sunday, December 3, 2:00-2:45 pm
Location: Theater 1
We will introduce you to the publicly available data, tools, observations, methods, and cell lines produced by the Allen Institute for Cell Science. Learn about our legacy collection of endogenous fluorescently tagged human induced pluripotent stem cell lines highlighting key structures within the cell. See examples of, and how to navigate, our large, high replicate 3D image data sets showing the subcellular localization of each of these tagged structures, and hear about our microscopy pipeline. We will discuss instrumentation, automation, quality control, and 3D segmentations using the recently released CellProfiler 3.0. These data are integrated using deep neural networks to generate unified, integrated cell models. Take a guided tour through our website (http://www.allencell.org) and find out how our work can help you.
Subgroup J: Building a multiscale, multidimensional Human Cell Atlas
Date & Time: Saturday, December 2, 8:30am-12:30pm
Location: Room 119A
Organizers: Emma Lundberg, Royal Institute of Technology KTH, Human Protein Atlas; Richard Conroy, National Institutes of Health; and Jonah Cool, Chan Zuckerberg Initiative
11:00-11:20am: Creating a dynamic, high dimensional stem cell atlas, Rick Horwitz
The human body is composed of approximately 40 trillion cells, organized at different scales to create enormous functional diversity. The rapid emergence of technologies for multiplexed and high throughput molecular mapping is driving a deeper understanding of the relationship between molecular profiles, cellular descriptors, and functional measures. The creation of a multiscale, multidimensional atlas will require a massive community effort but provide the framework for understanding cellular functionality across the lifespan and the health-disease continuum. In this session we will discuss international programs that are supporting this community effort and some of the novel imaging approaches that will inform modeling of cellular organization and interactions in tissue environments. There will be discussions with all speakers addressing challenges related to the creation of such a human cell atlas.
Subgroup N: Building the Cell 2017
Date & Time: Saturday, December 2, 1:30pm-5:30pm
Location: Room 120B
Organizer: Susanne Rafelski, Allen Institute for Cell Science; and Steph Weber, McGill University
4:50-5:10 pm: Capturing variance: integrating a moving target, Molly Maleckar
Modern cell biology has made great strides in understanding cell structure and function. As with any engineering problem, however, there is a third important aspect that needs to be understood besides structure and function, and that is assembly. How are the complex three-dimensional structures found within the cell specified by a one-dimensional genome? In this session we will explore the mechanisms by which cellular structures are determined and regulated. Because this question lies at the interface of biology and physics, this Building the Cell session will be highly interdisciplinary with speakers whose interests range from physics and mathematical modeling to biochemistry and cell biology.
Subgroup S: Sharing and Reusing Cell Imaging Data
Date & Time: Saturday, December 2, 1:30-5:30 pm
Location: Room 119B
4:10-4:30 pm: The Allen Institute for Cell Science: Building tools and sharing data to empower the scientific community, Winfried Wiegraebe
The rapid growth in content and complexity of cell imaging data creates an opportunity for synergy between experimental and computational scientists. Sharing microscopy data enable computational scientists to develop algorithms and tools for data analysis, integration, and mining. These tools can be applied by experimentalists to promote discovery. We are now at the dawn of this revolution: Infrastructure is constantly being developed for data standardization, deposition, sharing, and analysis; journals and funding agencies mandate data deposition; data journals publish high-content microscopy datasets; quantification becomes standard in scientific publications; new analytic tools are being developed and dispatched to the community. This subgroup will bring together scientists to reflect on opening cell imaging data and the opportunities that will come along with it.
Minisymposium 6: Regulation of Cell Size, Mitosis and Meiosis
Date & Time: Sunday, December 3, 4:15pm
Location: Room 108A
5:05 pm: Integrated cytoplasmic reorganization during human iPS cell mitosis, Susanne Rafelski
Sunday, December 3
B57/P1056 Systematic gene tagging to illuminate stem cell organization
B56/P1055 Designing an imaging pipeline for gene edited hiPSC-derived cardiomyocytes
Monday, December 4
B43/P1906 An image-based data generation pipeline to model stem cell organization and dynamics
Allen Institute team
B205/P2064 Integrated cytoplasmic reorganization during human iPS cell mitosis
B44/P1907 Toward the creation of the first 3D image-based data collection of drug induced signatures of endogenous fluorescently tagged human induced pluripotent stem cells lines
Allen Institute team