Staff Profiles

Irina Mueller, Ph.D.

Scientific Program Manager

Irina has been a member of the Assay Development group at the Allen Institute for Cell Science since 2015. She is involved in the development of live-cell, imaged-based quantitative assays.

Irina obtained her PhD in Molecular Biology and Biochemistry from the University of Alaska, Fairbanks in the laboratory of Kristin O’Brien. Her PhD project investigated the inter-relationship of mitochondrial structure and function and its effect on thermal tolerance in red- and white-blooded Antarctic fishes. Irina holds a diploma in biology from the Eberhard Karls Universitӓt Tübingen, Germany. Prior to joining the Allen Institute for Cell Science, Irina was a postdoctoral scholar in Susanne Rafelski’s laboratory at the University of California, Irvine. There, Irina’s work focused on developing quantitative, live cell and microscopy-based assays to study mitochondrial function and structure in single budding yeast cells during mitochondrial dysfunctions.


Research Interests

I am interested in understanding the inter-relationship of the structure and function of organelles and how this relationship affects the cell across multiple scales.


  • Mitochondrial bioenergetics
  • Mammalian and non-mammalian cell culture
  • Assay development and
  • Live cell imaging

Research Programs

  • Assay Development

Selected Publications

Scarless gene tagging of transcriptionally silent genes in hiPSCs to visualize cardiomyocyte sarcomeres in live cells

June 9, 2018

Roberts B, Arakaki J, Gerbin KA, Malik H, Nelson A, Hendershott MC, Hookway C, Ludmann SA, Mueller IA, Yang R, Rafelski SM, Gunawardane RN

The Allen Cell Structure Segmenter: a new open source toolkit for segmenting 3D intracellular structures in fluorescence microscopy images

December 8, 2018

Chen J, Ding L, Viana MP, Hendershott MC, Yang R, Mueller IA, Rafelski S