Brock Roberts, Ph.D.
Scientist
Brock leads the genome engineering team at the Allen Institute for Cell Science, and has been involved in the production of human induced pluripotent stem cell lines for the larger community as part of the Allen Cell Collection since the Institute's inception. Brock joined the Institute soon after completing his Ph.D. in Molecular and Cell Biology at UC Berkeley, where he performed some genome engineering experiments in mouse embryonic stem cells with exogenous nucleases in order to mechanistically dissect the role of the Hedgehog signaling pathway in patterning of the spinal cord.
Research
Research Interests
Brock is interested in genome engineering and cellular signaling pathways functioning in early human development, and how those two interests merge. The mechanistic determinants of cellular diversity produced by developmental events and changes in the cell's state are primary interest.
Expertise:
- Genetics
- Molecular Biology
- Stem Cell Biology
- Developmental Biology
Research Programs:
- Stem Cells
- Gene Editing
Selected Publications
Fluorescent Gene Tagging of Transcriptionally Silent Genes in hiPSCs
Stem Cell Reports
April 4, 2019
Roberts B, Hendershott MC, Arakaki J, Gerbin KA, Malik H, Nelson A, Gehring J, Hookway C, Ludmann SA, Yang R, Haupt A, Grancharova T, Valencia V, Fuqua MA, Tucker A, Rafelski SM, Gunawardane RN
Endogenous Protein Tagging in Human Induced Pluripotent Stem Cells Using CRISPR/Cas9
Jove
August 25, 2018
Haupt A, Grancharova T, Arakaki J, Fuqua MA, Roberts B, Gunawardane RN
bioRxiv
June 9, 2018
Roberts B, Arakaki J, Gerbin KA, Malik H, Nelson A, Hendershott MC, Hookway C, Ludmann SA, Mueller IA, Yang R, Rafelski SM, Gunawardane RN