The Distinguished Seminar Series features presentations by outstanding thinkers and scientists, sponsored by the Allen Institute for Brain Science. Distinguished speakers are selected based on the impact of their interdisciplinary research to the neuroscience community. Speakers spend a full day visiting with research staff, are nominated by members of the Allen Institute, and selected by a committee of peers.
We welcome members of the broader community to join us for these open seminars. See below for a schedule of upcoming speakers and view video presentations from past speakers. Seminars take place from 10:30-11:30 a.m. in the Allen Institute Auditorium. Register for the upcoming seminars below.
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Danielle Bassett, University of Pennsylvania | October 30, 2019
Perturbation and Control for Human Brain Network Dynamics
The human brain is a complex organ characterized by heterogeneous patterns of interconnections. New non-invasive imaging techniques now allow for these patterns to be carefully and comprehensively mapped in individual humans, paving the way for a better understanding of how wiring supports our thought processes. While a large body of work now focuses on descriptive statistics to characterize these wiring patterns, a critical open question lies in how the organization of these networks constrains the potential repertoire of brain dynamics. In this talk, I will describe an approach for understanding how perturbations to brain dynamics propagate through complex wiring patterns, driving the brain into new states of activity. Drawing on a range of disciplinary tools – from graph theory to network control theory and optimization – I will identify control points in brain networks, characterize trajectories of brain activity states following perturbation to those points, and propose a mechanism for how network control evolves in our brains as we grow from children into adults. Finally, I will describe how these computational tools and approaches can be used to better understand the brain’s intrinsic control mechanisms and to inform stimulation devices to control abnormal brain dynamics, for example in patients with medically refractory epilepsy.
Danielle S Bassett is the J Peter Skirkanich Professor at the University of Pennsylvania, with affiliations in the Departments of Bioengineering, Physics & Astronomy, Electrical & Systems Engineering, Neurology, and Psychiatry. She is also an External Professor at the Santa Fe Institute.
Alcino Silva, University of California, Los Angeles | November 21, 2019
Molecular, cellular, and circuit mechanisms that open and close the window for memory linking across time
Alcino J. Silva is director of the UCLA Integrative Center for Learning and Memory and Distinguished Professor in the Departments of Neurobiology, Psychiatry, and Psychology at the University of California, Los Angeles. He is a pioneer in the field of Molecular and Cellular Cognition. In 2002, he founded and became the first President of the Molecular and Cellular Cognition Society. In 2006/2007 he served as Scientific Director of the Intramural Program of the National Institute of Mental Health. His laboratory is searching for the molecular, cellular and circuit processes that underlie the allocation, encoding, and storage of information in the brain. Insights into mechanisms of memory are being used to unravel the causes and develop treatments for cognitive deficits associated with aging, intellectual disabilities, and autism.
Carlos Brody, Princeton University | Date to be announced
Talk title coming soon
Carlos Brody is the Wilbur H. Gantz III '59 Professor in Neuroscience, Professor of Molecular Biology, and Professor in the Princeton Neuroscience Institute.
Nelson Spruston, HHMI Janelia Research Campus | September 12, 2019
Deciphering the function of specific cell types in memory circuits
A major goal of biology is to understand complex physiological systems in terms of their cell types. What are the cell types? How do their properties and interrelationships allow the system to function? Our progress toward understanding hippocampus-dependent spatial memory in the mouse includes our efforts to provide unified descriptions of hippocampal cell types based on gene expression, morphology, circuit integration, and cellular function. This approach has allowed us to make new discoveries about hippocampal cell types and begin to explore cell-type-specific contributions to spatial memory, and we continue to develop a better understanding of the cellular and circuit basis of spatial memory.
Nelson Spruston is the Senior Director of Scientific Programs at the Janelia Research Campus, where he leads the Science and Training team. The group coordinates a number of science-related operations at Janelia. Spruston also oversees the Gene-Targeting and Transgenics resource. Spruston's lab explores the role of the hippocampus in learning and memory with an emphasis on the properties of a diverse collection of cell types.
Karen Rommelfanger, Emory University | July 18, 2019
No longer unthinkable: Neuroethics questions for the 21st century neuroscientist
Karen Rommelfanger is the Program Director of Emory University’s Neuroethics Program at the Center for Ethics and Assistant Professor in the Department of Neurology and Department of Psychiatry at Emory University.
Some have dubbed our current moment as the “Golden Era of Brain Science” wherein the revolution in neuroscience has prompted scientists to ask questions that were once unthinkable. Advances in neuroscience proffer new insights into fundamental and precious features of human existence such as memories, desires, emotion, and even demarcations of life and death. Such scientific promise is not just a matter of knowledge and health, but also of commerce and national pride. Our ever-expanding global neuroscience landscape requires that we, as a society and as scientists, consider the underlying values and ethics that drive brain research across culture and continents.
Ivan Soltesz, Stanford University | April 24, 2019
Organization and Control of Hippocampal Circuits
Ivan Soltesz Ph.D. is the James R. Doty Professor of Neurosurgery and Neurosciences at Stanford University School of Medicine. He received his doctorate in Budapest, and conducted postdoctoral research at Oxford, London, Stanford and Dallas. He established his laboratory at UC Irvine in 1995, where he served as department Chair from 2006 until his return to Stanford in 2015. His lab is interested in the nature of inhibition in the CNS, focusing on the synaptic and cellular organization of GABAergic microcircuits in the hippocampus under normal conditions and in temporal lobe epilepsy. Dr. Soltesz’ lab employs a combination of closely integrated experimental and theoretical techniques, including closed-loop optogenetics, in vivo electrophysiology and 2P calcium imaging, AI-aided segmentation of behavior, and large-scale computational modeling methods using supercomputers. He wrote an acclaimed book on GABAergic microcircuits “Diversity in the Neuronal Machine”, and he is the recipient of several awards, including the Javits Neuroscience award from NINDS, the international Michael Prize for basic epilepsy research, and the American Epilepsy Society’s Research Recognition Award.
Sebastian Seung, Princeton University | January 10, 2019
Models of cortical learning are constrained by functional connectomics
Sebastian Seung is Anthony B. Evnin Professor in the Neuroscience Institute and Computer Science Department at Princeton University, and Chief Research Scientist at Samsung Electronics. Seung has done influential research in both computer science and neuroscience. Over the past decade, he helped pioneer the new field of connectomics, applying deep learning and crowdsourcing to reconstruct neural circuits from electron microscopic images. His lab created EyeWire.org, a site that has recruited over 250,000 players from 150 countries to a game to map neural connections. His book Connectome: How the Brain's Wiring Makes Us Who We Are was chosen by the Wall Street Journal as Top Ten Nonfiction of 2012. Before joining the Princeton faculty in 2014, Seung studied at Harvard University, worked at Bell Laboratories, and taught at the Massachusetts Institute of Technology. He is External Member of the Max Planck Society, and winner of the 2008 Ho-Am Prize in Engineering.
Yang Dan, University of California, Berkeley | November 16, 2018
Neural Circuits Controlling Sleep
Yang Dan is Paul Licht Distinguished Professor in the Department of Molecular and Cell Biology and an investigator of the Howard Hughes Medical Institute at the University of California, Berkeley. She studied physics as an undergraduate student at Peking University and received her Ph.D. training in Biological Sciences at Columbia University, where she worked on cellular mechanisms of neurotransmitter secretion and synaptic plasticity. She did her postdoctoral research on information coding in the visual system at Rockefeller University and Harvard Medical School. Using a combination of electrophysiology, imaging, and computational methods, Dan’s lab has made important contributions to understanding the microcircuits underlying cortical computation, cellular mechanisms for functional plasticity, and neuromodulation of sensory processing.
Jessica Cardin, Yale University | October 9, 2018
State-dependent cortical circuits
Dr. Cardin is an associate professor of neuroscience at the Yale University School of Medicine, where her lab studies the flexible function of cortical circuits in health and developmental disease. Her lab at Yale uses a multilevel electrophysiological and optical approach to explore the dynamic interactions between inhibitory and excitatory neurons that underlie the flexible encoding of visual information in cortical circuits, and how cortical circuit function varies with behavioral state and learning. The Cardin lab also studies how developmental dysregulation of cortical circuits leads to compromised perceptual and cognitive function in models of autism and schizophrenia.
Li-Huei Tsai, Massachusetts Institute of Technology | September 20, 2018
Transcriptomic analysis of Alzheimer's disease at the single cell resolution
Professor Li-Huei Tsai is Director of the Picower Institute for Learning and Memory at the Massachusetts Institute of Technology, a Picower Professor of Neuroscience, and an Associate Member of the Broad Institute. Tsai is also a Fellow of the American Association for the Advancement of Science, a member of the National Academy of Medicine, and an Academician of the Academia Sinica in Taiwan.
Tsai is interested in elucidating the pathogenic mechanisms underlying neurological disorders that impact learning and memory. She takes a multidisciplinary approach to investigate the molecular, systems, and circuit basis of neurodegenerative disorders. Recent contributions include the identification of chromatin remodeling as a means to regulate memory gene expression and enhance cognitive function during neurodegeneration. Her lab also conducts epigenomic analysis of mouse and human Alzheimer’s disease (AD) brain samples and has identified important contributions of dysregulated immune response genes in AD. Currently, the Tsai lab uses induced pluripotent stem cells (iPSCs) derived from human subjects to model AD and large scale imaging, optogenetics, and in vivo electrophysiology to study the brain circuitry affected by AD. Recently, she and her colleagues invented a non-‐invasive sensory stimulation technology that proved effective in reducing AD pathology on animal models.
Kenneth Harris, University College London | April 27, 2018
Brain-wide patterns of neural activity underlying a visual decision task
Professor Harris studied mathematics at Cambridge University, obtained his PhD in robotics at University College London, then moved to Rutgers University in the United States for postdoctoral work in neuroscience. Before returning to UCL in 2012, he was Associate Professor of Neuroscience at Rutgers, and Professor of Neurotechnology at Imperial College London. Together with Matteo Carandini, he directs the Functional Neuromics Lab at UCL, which aims to understand how the brain processes sensory signals, and integrates them with internal signals to guide decision and action. The lab investigates these questions with a combination of experiment and computational analysis.
Hillel Adesnik, University of California, Berkeley | March 2, 2018
Optically probing the neural basis of perception
Dr. Adesnik is an assistant professor of neurobiology at UC Berkeley, where his labs studies the neural basis of sensory perception. He obtained a PhD from UCSF in synaptic physiology with Roger Nicoll, and did his postdoctoral fellowhsip at UCSD with Massimo Scanziani where he studied the structure and function of cortical inhibitory circuits. His lab at Berkeley develops and leverages novel optical tools to manipulate neural activity in the brains of behaving animals to understand the synaptic and circuit basis of neural computation in the sensory cortex.
Hilton Lewis, W. M. Keck Observatory | February 9, 2018
Sociology of the Astronomy Community - Organization and Challenges
As Director, Lewis is responsible for the operation and performance of the observatory with its twin 10-meter optical/infrared telescopes, and for the development of new capabilities. Lewis works closely with the staff, partner institutions and scientists to ensure the continued success of the Keck Observatory and foster the development of its scientific capabilities and overall productivity.
Lewis was recruited in 1986 to lead the design and development of the software that controls the Keck Observatory’s twin, 10-meter telescopes. He has held many leadership roles throughout the history of the Observatory, ranging from leading software development to overseeing the full range of technical activities at the observatory.
Lewis holds a B.S. in Electrical Engineering from the University of Cape Town and earned his MBA from the University of Hawai’i at Manoa. His professional interests include leadership and motivation of high tech teams, strategic planning, multiple-year plan design, and effective project planning and execution.
Lewis has dedicated his career to building, operating and updating the most sophisticated ground- based optical/infrared telescopes in the world, a commitment that has contributed to the unprecedented astronomical innovation and forefront science of the W. M. Keck Observatory.