Travis Hage
Senior Scientist
Travis Hage joined the Allen Institute in 2016 to help perform electrophysiology and photostimulation experiments to unravel cortical microcircuitry. Travis received his undergraduate training in Biology at the University of Texas in Austin. As part of a senior thesis with Dr. Nace Golding, Travis helped characterize the cellular physiology of an auditory brainstem circuit. Travis then went on to graduate school at Washington University in St. Louis. As a student in Lawrence Salkoff’s laboratory he used whole-cell electrophysiology and single channel recordings to uncover unique aspects of potassium channel and sodium channel function. Before joining the Allen Institute, Travis was a postdoc in Dr. Zayd Khaliq’s lab at the National Institutes of Health Intramural Research Program. There, he used a combination of electrophysiology, two photon imaging and photostimulation to study cellular physiology and synaptic integration in midbrain dopamine neurons.
Research
Research Interests
My long-term research interests are centered around understanding the rules by which neurons transform their inputs into their outputs. There are many components to this subject, but chief among them is understanding the patterns of connectivity amongst different classes and types of neurons. I am interested in combining whole-cell electrophysiology with modern imaging and optogenetic techniques to perform experiments that would not be possible if utilizing these methods in isolation. Working at the Allen Institute also provides the unique opportunity to test new genetic tools and work across teams to obtain multi-modal datasets on the same pieces of tissue.
Expertise
Cellular and Synaptic Physiology
Research Interests
- Cell Types
- Synaptic Physiology
Selected Publications
Local connectivity and synaptic dynamics in mouse and human neocortex
Science
March 11, 2022
Campagnola L, Seeman SC, Chartrand T, Kim L, Hoggarth A, Gamlin C, Ito S, Trinh J, Davoudian P, Radaelli C, Kim MH, Hage T, Braun T, Alfiler L, Andrade J, Bohn P, Dalley R, Henry A, Kebede S, Alice M, Sandman D, Williams G, Larsen R, Teeter C, Daigle TL, Berry K, Dotson N, Enstrom R, Gorham M, Hupp M, Dingman Lee S, Ngo K, Nicovich PR, Potekhina L, Ransford S, Gary A, Goldy J, McMillen D, Pham T, Tieu M, Siverts L, Walker M, Farrell C, Schroedter M, Slaughterbeck C, Cobb C, Ellenbogen R, Gwinn RP, Keene CD, Ko AL, Ojemann JG, Silbergeld DL, Carey D, Casper T, Crichton K, Clark M, Dee N, Ellingwood L, Gloe J, Kroll M, Sulc J, Tung H, Wadhwani K, Brouner K, Egdorf T, Maxwell M, McGraw M, Pom CA, Ruiz A, Bomben J, Feng D, Hejazinia N, Shi S, Szafer A, Wakeman W, Phillips J, Bernard A, Esposito L, D'Orazi FD, Sunkin S, Smith K, Tasic B, Arkhipov A, Sorensen S, Lein E, Koch C, Murphy G, Zeng H, Jarsky T
eLife
January 21, 2022
Hage TA, Bosma-Moody A, Baker CA, Kratz MB, Campagnola L, Jarsky T, Zeng H, Murphy GJ
Sparse recurrent excitatory connectivity in the microcircuit of the adult mouse and human cortex
eLife
September 26, 2018
Seeman SC, Campagnola L, Davoudian PA, Hoggarth A, Hage TA, Bosma-Moody A, Baker CA, Lee, JH, Mihalas S, Teeter C, Ko AL, Ojemann JG, Gwinn RP, Silbergeld DL, Cobbs C, Phillips J, Lein E, Murphy G, Koch C, Zeng H, Jarsky T
Cell
July 12, 2018
Daigle TL, Madisen L, Hage TA, Valley MT, Knoblich U, Larsen RS, Takeno MM, Huang L, Gu H, Larsen R, Mills M, Bosma-Moody A, Siverts LA, Walker M, Graybuck LT, Yao Z, Fong O, Nguyen TN, Garren E, Lenz GH, Chavarha M, Pendergraft J, Harrington J, Hirokawa KE, Harris JA, Nicovich PR, McGraw MJ, Ollerenshaw DR, Smith KA, Baker CA, Ting JT, Sunkin SM, Lecoq J, Lin MZ2, Boyden ES, Murphy GJ, da Costa NM, Waters J, Li L, Tasic B, Zeng H