
Stephanie Seeman, Ph.D.
Scientist II
Stephanie joined the Allen Institute for Brain Science in 2016 to aid in research efforts exploring circuit connectivity and processing in mouse visual cortex. Stephanie earned her Ph.D. in Neuroscience from the University of Washington. There she worked with Dr. Steve Perlmutter and Dr. Eberhard Fetz to understand the connectivity and plasticity of sensorimotor cortex using in vivo recordings of population local field potentials. Stephanie previously researched synaptic processing in the auditory brainstem using in vitro electrophysiological methods under Dr. Nace Golding at the University of Texas, Austin. Stephanie earned her B.S. in Biology from Union College in Schenectady, NY.

Research
Research Interests
The complex processing of the brain is intimately tied to the structural and functional connections that individual neurons and networks of neurons make. For many decades anatomical studies have guided us as to which brain regions and local populations likely make synaptic contact. I am interested in understanding the functional interactions served by these physical connections as this is how the brain communicates. With the multi-patch team I will record from many neurons simultaneously to uncover the transmission of neural signals between them. By utilizing transgenic mouse lines we can describe the connections of specific neuron types in order to form a rich view of specific connectivity in the brain and ultimately how this leads to behavior.
Expertise
- In vivo and in vitro electrophysiology
- Systems Neuroscience
- Neural Circuits
- Synaptic Plasticity
Research Programs
- Ephys Core
- Multi-patch
Selected Publications
Local connectivity and synaptic dynamics in mouse and human neocortex
Science
March 11, 2022
Campagnola L, Seeman SC, Chartrand T, Kim L, Hoggarth A, Gamlin C, Ito S, Trinh J, Davoudian P, Radaelli C, Kim MH, Hage T, Braun T, Alfiler L, Andrade J, Bohn P, Dalley R, Henry A, Kebede S, Alice M, Sandman D, Williams G, Larsen R, Teeter C, Daigle TL, Berry K, Dotson N, Enstrom R, Gorham M, Hupp M, Dingman Lee S, Ngo K, Nicovich PR, Potekhina L, Ransford S, Gary A, Goldy J, McMillen D, Pham T, Tieu M, Siverts L, Walker M, Farrell C, Schroedter M, Slaughterbeck C, Cobb C, Ellenbogen R, Gwinn RP, Keene CD, Ko AL, Ojemann JG, Silbergeld DL, Carey D, Casper T, Crichton K, Clark M, Dee N, Ellingwood L, Gloe J, Kroll M, Sulc J, Tung H, Wadhwani K, Brouner K, Egdorf T, Maxwell M, McGraw M, Pom CA, Ruiz A, Bomben J, Feng D, Hejazinia N, Shi S, Szafer A, Wakeman W, Phillips J, Bernard A, Esposito L, D'Orazi FD, Sunkin S, Smith K, Tasic B, Arkhipov A, Sorensen S, Lein E, Koch C, Murphy G, Zeng H, Jarsky T
Bright and photostable chemigenetic indicators for extended in vivo voltage imaging
Science
August 16, 2019
Abdelfattah AS, Kawashima T, Singh A, Novak O, Liu H, Shuai Y, Huang YC, Campagnola L, Seeman SC, Yu J, Zheng J, Grimm JB, Patel R, Friedrich J, Mensh BD, Paninski L, Macklin JJ, Murphy GJ, Podgorski K, Lin BJ, Chen TW, Turner GC, Liu Z, Koyama M, Svoboda K, Ahrens MB, Lavis LD, Schreiter ER
Sparse recurrent excitatory connectivity in the microcircuit of the adult mouse and human cortex
eLife
September 26, 2018
Seeman SC, Campagnola L, Davoudian PA, Hoggarth A, Hage TA, Bosma-Moody A, Baker CA, Lee, JH, Mihalas S, Teeter C, Ko AL, Ojemann JG, Gwinn RP, Silbergeld DL, Cobbs C, Phillips J, Lein E, Murphy G, Koch C, Zeng H, Jarsky T
Frontiers in Neural Circuits
May 15, 2014
Roberts MT, Seeman SC, Golding NL
Neuron
June 5, 2013
Roberts MT, Seeman SC, Golding NL