Team

Staff Profiles

Stephanie Seeman, Ph.D.

Scientist II

Stephanie joined the Allen Institute for Brain Science in 2016 to aid in research efforts exploring circuit connectivity and processing in mouse visual cortex. Stephanie earned her Ph.D. in Neuroscience from the University of Washington. There she worked with Dr. Steve Perlmutter and Dr. Eberhard Fetz to understand the connectivity and plasticity of sensorimotor cortex using in vivo recordings of population local field potentials. Stephanie previously researched synaptic processing in the auditory brainstem using in vitro electrophysiological methods under Dr. Nace Golding at the University of Texas, Austin. Stephanie earned her B.S. in Biology from Union College in Schenectady, NY.

Research

Research Interests

The complex processing of the brain is intimately tied to the structural and functional connections that individual neurons and networks of neurons make. For many decades anatomical studies have guided us as to which brain regions and local populations likely make synaptic contact. I am interested in understanding the functional interactions served by these physical connections as this is how the brain communicates. With the multi-patch team I will record from many neurons simultaneously to uncover the transmission of neural signals between them. By utilizing transgenic mouse lines we can describe the connections of specific neuron types in order to form a rich view of specific connectivity in the brain and ultimately how this leads to behavior.

Expertise

  • In vivo and in vitro electrophysiology
  • Systems Neuroscience
  • Neural Circuits
  • Synaptic Plasticity

Research Programs

  • Ephys Core
  • Multi-patch

Selected Publications

Local connectivity and synaptic dynamics in mouse and human neocortex

Science
March 11, 2022

Campagnola L, Seeman SC, Chartrand T, Kim L, Hoggarth A, Gamlin C, Ito S, Trinh J, Davoudian P, Radaelli C, Kim MH, Hage T, Braun T, Alfiler L, Andrade J, Bohn P, Dalley R, Henry A, Kebede S, Alice M, Sandman D, Williams G, Larsen R, Teeter C, Daigle TL, Berry K, Dotson N, Enstrom R, Gorham M, Hupp M, Dingman Lee S, Ngo K, Nicovich PR, Potekhina L, Ransford S, Gary A, Goldy J, McMillen D, Pham T, Tieu M, Siverts L, Walker M, Farrell C, Schroedter M, Slaughterbeck C, Cobb C, Ellenbogen R, Gwinn RP, Keene CD, Ko AL, Ojemann JG, Silbergeld DL, Carey D, Casper T, Crichton K, Clark M, Dee N, Ellingwood L, Gloe J, Kroll M, Sulc J, Tung H, Wadhwani K, Brouner K, Egdorf T, Maxwell M, McGraw M, Pom CA, Ruiz A, Bomben J, Feng D, Hejazinia N, Shi S, Szafer A, Wakeman W, Phillips J, Bernard A, Esposito L, D'Orazi FD, Sunkin S, Smith K, Tasic B, Arkhipov A, Sorensen S, Lein E, Koch C, Murphy G, Zeng H, Jarsky T

Bright and photostable chemigenetic indicators for extended in vivo voltage imaging

Science
August 16, 2019

Abdelfattah AS, Kawashima T, Singh A, Novak O, Liu H, Shuai Y, Huang YC, Campagnola L, Seeman SC, Yu J, Zheng J, Grimm JB, Patel R, Friedrich J, Mensh BD, Paninski L, Macklin JJ, Murphy GJ, Podgorski K, Lin BJ, Chen TW, Turner GC, Liu Z, Koyama M, Svoboda K, Ahrens MB, Lavis LD, Schreiter ER

Sparse recurrent excitatory connectivity in the microcircuit of the adult mouse and human cortex

eLife
September 26, 2018

Seeman SC, Campagnola L, Davoudian PA, Hoggarth A, Hage TA, Bosma-Moody A, Baker CA, Lee, JH, Mihalas S, Teeter C, Ko AL, Ojemann JG, Gwinn RP, Silbergeld DL, Cobbs C, Phillips J, Lein E, Murphy G, Koch C, Zeng H, Jarsky T

The relative contributions of MNTB and LNTB neurons to inhibition in the medial superior olive assessed through single and paired recordings

Frontiers in Neural Circuits
May 15, 2014

Roberts MT, Seeman SC, Golding NL

A mechanistic understanding of the role of feedforward inhibition in the mammalian sound localization circuitry

Neuron
June 5, 2013

Roberts MT, Seeman SC, Golding NL

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