Team

Staff Profiles

Matthew Valley, Ph.D.

Scientist II

Matt joined the Allen Institute in 2014 as a member of the Neural Coding group where he studies cortical systems engaged in visual sensory processing. Matt majored in Neuroscience at Carleton College and received his PhD with Stuart Firestein at Columbia University in New York. There, he studied the functional impact of adult-neurogenesis on olfactory bulb circuits.  This work continued during his postdoc with Pierre-Marie Lledo at the Pasteur Institute in Paris where he broadened his technical expertise in electrophysiology and optophysiology. Today, Matt is thrilled to explore the mouse visual system as a part of the large-scale neurophysiology efforts underway at the Allen Institute.

Research

Research Interests

Our perception of the outside world is heavily influenced by prior knowledge and expectation, but little is known about how this sort of contextual information influences the different stages of sensory processing. At the Allen Institute I am excited to be able to explore this question as part of a general effort to understand how visual stimuli are processed to drive behavior. In particular, I am working to dissect the cortical systems engaged during visuo-locomotor behavior. For this, I combine behavioral analysis, functional imaging of neural activity, and perturbation of cortical systems.

Expertise

  • Sensory neuroscience
  • In vitro and in vivo electrophysiology
  • Two-photon imaging

Research Programs

  • Neural Coding

Selected Publications View on PUBMED

A Suite of Transgenic Driver and Reporter Mouse Lines with Enhanced Brain-Cell-Type Targeting and Functionality

Cell
July 12, 2018

Daigle TL, Madisen L, Hage TA, Valley MT, Knoblich U, Larsen RS, Takeno MM, Huang L, Gu H, Larsen R, Mills M, Bosma-Moody A, Siverts LA, Walker M, Graybuck LT, Yao Z, Fong O, Nguyen TN, Garren E, Lenz GH, Chavarha M, Pendergraft J, Harrington J, Hirokawa KE, Harris JA, Nicovich PR, McGraw MJ, Ollerenshaw DR, Smith KA, Baker CA, Ting JT, Sunkin SM, Lecoq J, Lin MZ2, Boyden ES, Murphy GJ, da Costa NM, Waters J, Li L, Tasic B, Zeng H

Persistent Structural Plasticity Optimizes Sensory Information Processing in the Olfactory Bulb

Neuron
June 30, 2016

Sailor KA, Valley MT, Wiechert MT, Riecke H, Sun GJ, Adams W, Dennis JC, Sharafi S, Ming GL, Song H, Lledo PM

Adult neurogenesis produces neurons with unique GABAergic synapses in the olfactory bulb

Journal of Neuroscience
September 11, 2013

Valley MT, Henderson LG, Inverso SA, Lledo PM

Ablation of mouse adult neurogenesis alters olfactory bulb structure and olfactory fear conditioning

Frontiers in Neuroscience
November 16, 2009

Valley MT, Mullen TR, Schultz LC, Sagdullaev BT, Firestein S

Olfactory behavior and physiology are disrupted in prion protein knockout mice

Nature Neuroscience
January 2009

Le Pichon CE, Valley MT, Polymenidou M, Chesler AT, Sagdullaev BT, Aguzzi A, Firestein S