Staff Profiles

Lawrence Huang, Ph.D.

Scientist I

Lawrence Huang joined the Allen Institute for Brain Science in 2016. He is part of a team in Structured Science that seeks to link the physiological and morphological properties of neuronal cell types in the mouse primary visual cortex. Before joining the Allen Institute, Lawrence was a postdoctoral fellow in Rong Wang’s lab at the University of California, San Francisco. There, he combined in vivo two-photon imaging and transgenic mouse models to study brain arteriovenous malformation, a cerebrovascular disease that is accompanied by hemorrhage, stroke, and neurological deficit. Lawrence received a B.S. in Biomedical Engineering from Johns Hopkins University, and a Ph.D. in Biomedical Engineering from the University of Virginia, where he investigated mechanisms by which endothelial cells respond to hemodynamic forces.


Research Interests

I am interested in utilizing imaging approaches to characterize cell structure and function. At the Allen Institute, I hope to contribute to the understanding of integrated cellular and network properties of neuronal cell types in the mouse primary visual cortex. To this end, I will utilize transgenic mouse lines and combined electrophysiology and optical physiology to correlate cellular spiking activity and calcium signal.

Research Programs

  • Structured Science

Selected Publications

Relationship between simultaneously recorded spiking activity and fluorescence signal in GCaMP6 transgenic mice

March 8, 2021

Huang L, Ledochowitsch P, Knoblich U, Lecoq J, Murphy GJ, Reid RC, de Vries SEJ, Koch C, Zeng H, Buice MA, Waters J, Li L

Neuronal cell-subtype specificity of neural synchronization in mouse primary visual cortex

Nature Communications
June 10, 2019

Knoblich U, Huang L, Zeng H, Li L

A large-scale, standardized physiological survey reveals higher order coding throughout the mouse visual cortex

Nature Neuroscience
December 16, 2019

de Vries S, Lecoq J, Buice MA, Groblewski PA, Ocker GK, Oliver M, Feng F, Cain N, Ledochowitsch P, Millman D, Roll K, Garrett M, Keenan T, Kuan L, Mihalas S, Olsen S, Thompson C, Wakeman W, Waters J, Williams D, Barber C, Berbesque N, Blanchard B, Bowles N, Caldejon S, Casal L, Cho A, Cross S, Dang C, Dolbeare T, Edwards M, Galbraith J, Gaudreault N, Griffin F, Hargrave P, Howard R, Huang L, Jewell S, Keller N, Knoblich U, Larkin J, Larsen R, Lau C, Lee E, Lee F, Leon A, Li L, Long F, Luviano J, Mace K, Nguyen T, Perkins J, Robertson M, Seid S, Shea-Brown E, Shi J, Sjoquist N, Slaughterbeck C, Sullivan D, Valenza R, White C, Williford A, Witten D, Zhuang J, Zeng H, Farrell C, Ng L, Bernard A, Phillips JW, R Reid C, Koch C

A Suite of Transgenic Driver and Reporter Mouse Lines with Enhanced Brain-Cell-Type Targeting and Functionality

July 12, 2018

Daigle TL, Madisen L, Hage TA, Valley MT, Knoblich U, Larsen RS, Takeno MM, Huang L, Gu H, Larsen R, Mills M, Bosma-Moody A, Siverts LA, Walker M, Graybuck LT, Yao Z, Fong O, Nguyen TN, Garren E, Lenz GH, Chavarha M, Pendergraft J, Harrington J, Hirokawa KE, Harris JA, Nicovich PR, McGraw MJ, Ollerenshaw DR, Smith KA, Baker CA, Ting JT, Sunkin SM, Lecoq J, Lin MZ2, Boyden ES, Murphy GJ, da Costa NM, Waters J, Li L, Tasic B, Zeng H