Staff Profiles

Jim Berg, Ph.D.

Director, Scientific Operations

Jim Berg is the Director of Scientific Operations of a new research program in development at the Allen Institute, to be focused on neural dynamics. He joined the Allen Institute in 2012, leading the in vitro single cell characterization project where his team used patch clamp electrophysiology to characterize the morphoelectric properties of thousands of neurons from the mouse visual cortical and human neocortical sections, publicly released as part of the Allen Cell Types Database. To study each cell’s transcriptomic signature in addition to the morphoelectric properties, his team adopted the Patch-seq technique. Using a system of rapid feedback and increased automation, they increased the throughput and quality of the Patch-seq data to ultimately contribute >8,000 additional mouse and human neurons to the database. Previously he studied the role of the TMEM16A ion channel in pain processing as a postdoc at UCSF and engineered Perceval, a genetically encoded fluorescent sensor for energy metabolism, as a graduate student at Harvard University. Berg's first experiences with patch clamping were as an undergraduate at Rutgers University, where he studied potassium current in auditory neurons and earned a B.S. in neuroscience. Berg recently earned an MBA from the University of Washington with a focus on technology management.

Selected Publications View Publications

Alternating sources of perisomatic inhibition during behavior

January 27, 2021

Dudok B, Klein PM, Hwaun E, Lee BR, Yao Z, Fong O, Bowler JC, Terada S, Sparks FT, Szabo GG, Farrell JS, Berg J, Daigle TL, Tasic B, Dimidschstein J, Fishell G, Losonczy A, Zeng H, Soltesz I.

CamKIIα Positive Interneurons Identified via A microRNA Based Viral Gene Targeting Strategy

Journal of Neuroscience
November 5, 2020

Keaveney MK, Rahsepar B, Tseng HA, Fernandez FR, Mount RA, Ta T, White JA, Berg J, Han X

Integrated Morphoelectric and Transcriptomic Classification of Cortical GABAergic Cells

November 12, 2020

Gouwens NW, Sorensen SA, Baftizadeh F, Budzillo A, Lee BR, Jarsky T, Alfiler L, Baker K, Barkan E, Berry K, Bertagnolli D, Bickley K, Bomben J, Braun T, Brouner K, Casper T, Crichton K, Daigle TL, Dalley R, de Frates RA, Dee N, Desta T, Lee SD, Dotson N, Egdorf T, Ellingwood L, Enstrom R, Esposito L, Farrell C, Feng D, Fong O, Gala R, Gamlin C, Gary A, Glandon A, Goldy J, Gorham M, Graybuck L, Gu H, Hadley K, Hawrylycz MJ, Henry AM, Hill D, Hupp M, Kebede S, Kim TK, Kim L, Kroll M, Lee C, Link KE, Mallory M, Mann R, Maxwell M, McGraw M, McMillen D, Mukora A, Ng L, Ng L, Ngo K, Nicovich PR, Oldre A, Park D, Peng H, Penn O, Pham T, Pom A, Popović Z, Potekhina L, Rajanbabu R, Ransford S, Reid D, Rimorin C, Robertson M, Ronellenfitch K, Ruiz A, Sandman D, Smith K, Sulc J, Sunkin SM, Szafer A, Tieu M, Torkelson A, Trinh J, Tung H, Wakeman W, Ward K, Williams G, Zhou Z, Ting JT, Arkhipov A, Sümbül U, Lein ES, Koch C, Yao Z, Tasic B, Berg J, Murphy GJ, Zeng H

Classification of electrophysiological and morphological neuron types in mouse visual cortex

Nature Neuroscience
June 17, 2019

Gouwens NW, Sorensen SA, Berg J, Lee C, Jarsky T, Ting J, Sunkin S, Feng D, Anastassiou C, Barkan E, Bickley K, Blesie N, Braun T, Brouner K, Budzillo A, Caldejon S, Casper T, Castelli D, Chong P, Crichton K, Cuhaciyan C, Daigle T, Dalley R, Dee N, Desta T, Dingman S, Doperalski A, Dotson N, Egdorf T, Fisher M, de Frates RA, Garren E, Garwood M, Gary A, Gaudreault N, Godfrey K, Gorham M, Gu H, Habel C, Hadley K, Harrington J, Harris J, Henry A, Hill D, Josephsen S, Kebede S, Kim L, Kroll M, Lee B, Lemon T, Liu X, Long B, Mann R, McGraw M, Mihalas S, Mukora A, Murphy GJ, Ng L, Ngo K, Nguyen TN, Nicovich PR, Oldre A, Park D, Parry S, Perkins J, Potekhina L, Reid D, Robertson M, Sandman D, Schroedter M, Slaughterbeck C, Soler-Llavina C, Sulc J, Szafer A, Tasic B, Taskin N, Teeter C, Thatra N, Tung H, Wakeman W, Williams G, Young R, Zhou Z, Farrell C, Peng H, Hawrylycz MJ, Lein E, Ng L, Arkhipov A, Bernard A, Phillips J, Zeng H, Koch C

Systematic generation of biophysically detailed models for diverse cortical neuron types

Nature Communications
February 19, 2018

Gouwens NW, Berg J, Feng D, Sorensen SA, Zeng H, Hawrylycz MJ, Koch C, and Arkhipov A

Generalized leaky integrate-and-fire models classify multiple neuron types

Nature Communications
February 19, 2018

Teeter C, Iyer R, Menon V, Gouwens N, Feng D, Berg J, Szafer A, Cain N, Zeng H, Hawrylycz M, Koch C, Mihalas S

Visual physiology of the Layer 4 cortical circuit in silico

PLoS Computational Biology
November 12, 2018

Arkhipov A, Gouwens NW, Billeh YN, Gratiy S, Iyer R, Wei Z, Xu Z, Berg J, Buice M, Cain N, da Costa N, de Vries S, Denman D, Durand S, Feng D, Jarsky T, Lecoq J, Lee B, Li L, Mihalas S, Ocker GK, Olsen SR, Reid RC, Soler-LLavina G, Sorensen SA, Wang Q, Waters J, Scanziani M, Koch C

Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics

Genes & Development
August 2012

Huang X, Dubuc AM, Hashizume R, Berg J, He Y, Wang J, Chiang C, Cooper MK, Northcott PA, Taylor MD, Barnes MJ, Tihan T, Chen J, Hackett CS, Weiss WA, James CD, Rowitch DH, Shuman MA, Jan YN, Jan LY

Ca2+-activated Cl- channels at a glance

Journal of Cell Science
May 2012

Berg J, Yang H, Jan LY

A genetically encoded fluorescent reporter of ATP:ADP ratio

Nature Methods
February 2009

Berg, J, Hung YP, Yellen G

Ketogenic diet metabolites reduce firing in central neurons by opening KATP channels

Journal of Neuroscience
April 2007

Ma, W., Berg, J., Yellen, G

Truncated ClC-1 mRNA in myotonic dystrophy exerts a dominant-negative effect on the Cl current

December 2004

Berg J, Jiang H, Thornton CA, Cannon SC