Team

Staff Profiles

Elise Shen, M.S.

Research Associate II

elise.shen@alleninstitute.org

Elise is a research associate on the Experimental Immunology team. Elise received her B.S. in Biology-Neurobiology at the University of Texas at Austin, where she worked in the Center for Learning and Memory. Her points of focus included developing image analysis methods paired with surgery techniques for in-vivo injections and imaging surgeries in immature and mature mice for long-term cerebellar studies using two-photon microscopy. Elise earned her M.S. in Biomedical Engineering from National Taiwan University, where she studied an in-vivo fornix deep brain stimulation surgery in triple-transgenic Alzheimer’s disease mice using DT-MRI, PET, behavioral, and immunohistochemical assessments of therapy efficacy. Prior to the Allen Institute for Immunology, she worked at the Allen Institute for Brain Science and Baylor College of Medicine and Texas Children’s Hospital for a CRO, where she performed NGS and RNA-seq analysis and biostatistics in order to improve an immunotherapy for neuroblastoma.

Research

Research Interests

Elise's research interests include neurodegenerative diseases, cancer, and image reconstruction and analysis. She ultimately wants to combine image reconstruction and analysis with her biomedical engineering background for robotic surgery and artificial intelligence diagnosis applications.

Expertise

  • Multimodal Image Acquisition and Analysis
  • Small-animal surgery development
  • Bioinformatics

Research Programs

  • Experimental Immunology

Selected Publications

A multimodal cell census and atlas of the mammalian primary motor cortex

Nature
October 6, 2021

BRAIN Initiative Cell Census Network (BICCN)

Morphological diversity of single neurons in molecularly defined cell types

Nature
October 6, 2021

Peng H, Xie P, Liu L, Kuang X, Wang Y, Qu L, Gong H, Jiang S, Li A, Ruan Z, Ding L, Yao Z, Chen C, Chen M, Daigle TL, Dalley R, Ding Z, Duan Y, Feiner A, He P, Hill C, Hirokawa KE, Hong G, Huang L, Kebede S, Kuo HC, Larsen R, Lesnar P, Li L, Li Q, Li X, Li Y, Li Y, Liu A, Lu D, Mok S, Ng L, Nguyen TN, Ouyang Q, Pan J, Shen E, Song Y, Sunkin SM, Tasic B, Veldman MB, Wakeman W, Wan W, Wang P, Wang Q, Wang T, Wang Y, Xiong F, Xiong W, Xu W, Ye M, Yin L, Yu Y, Yuan J, Yuan J, Yun Z, Zeng S, Zhang S, Zhao S, Zhao Z, Zhou Z, Huang ZJ, Esposito L, Hawrylycz MJ, Sorensen SA, Yang XW, Zheng Y, Gu Z, Xie W, Koch C, Luo Q, Harris JA, Wang Y, Zeng H

Cellular anatomy of the mouse primary motor cortex

Nature
October 6, 2021

Muñoz-Castañeda R, Zingg B, Matho KS, Chen X, Wang Q, Foster NN, Li A, Narasimhan A, Hirokawa KE, Huo B, Bannerjee S, Korobkova L, Park CS, Park YG, Bienkowski MS, Chon U, Wheeler DW, Li X, Wang Y, Naeemi M, Xie P, Liu L, Kelly K, An X, Attili SM, Bowman I, Bludova A, Cetin A, Ding L, Drewes R, D'Orazi F, Elowsky C, Fischer S, Galbavy W, Gao L, Gillis J, Groblewski PA, Gou L, Hahn JD, Hatfield JT, Hintiryan H, Huang JJ, Kondo H, Kuang X, Lesnar P, Li X, Li Y, Lin M, Lo D, Mizrachi J, Mok S, Nicovich PR, Palaniswamy R, Palmer J, Qi X, Shen E, Sun YC, Tao HW, Wakemen W, Wang Y, Yao S, Yuan J, Zhan H, Zhu M, Ng L, Zhang LI, Lim BK, Hawrylycz M, Gong H, Gee JC, Kim Y, Chung K, Yang XW, Peng H, Luo Q, Mitra PP, Zador AM, Zeng H, Ascoli GA, Josh Huang Z, Osten P, Harris JA, Dong HW

Hierarchical organization of cortical and thalamic connectivity

Nature
October 30, 2019

Harris JA, Mihalas S, Hirokawa KE, Whitesell JD, Choi H, Bernard A, Bohn P, Caldejon S, Casal L, Cho A, Feiner A, Feng D, Gaudreault N, Gerfen CR, Graddis N, Groblewski PA, Henry AM, Ho A, Howard R, Knox JE, Kuan L, Kuang X, Lecoq J, Lesnar P, Li Y, Luviano J, McConoughey S, Mortrud MT, Naeemi M, Ng L, Oh SW, Ouellette B, Shen E, Sorensen SA, Wakeman W2, Wang Q2, Wang Y, Williford A, Phillips JW, Jones AR, Koch C, Zeng H

IL-21 Selectively Protects CD62L+ NKT Cells and Enhances Their Effector Functions for Adoptive Immunotherapy

Journal of Immunology
October 1, 2018

Ngai H, Tian G, Courtney AN, Ravari SB, Guo L, Liu B, Jin J, Shen ET, Di Pierro EJ, Metelitsa LS

Central Thalamic Deep-Brain Stimulation Alters Striatal-Thalamic Connectivity in Cognitive Neural Behavior

Frontiers in Neural Circuits
January 13, 2016

Lin HC, Pan HC, Lin SH, Lo YC, Shen ET, Liao LD, Liao PH, Chien YW, Liao KD, Jaw FS, Chu KW, Lai HY, Chen YY