Team

Staff Profiles

Costas Anastassiou, Ph.D.

Assistant Investigator

costasa@alleninstitute.org

Costas Anastassiou leads the translational neuroscience program at the Allen Institute, focusing on understanding brain disorders such as epilepsy and Alzheimer’s disease and developing novel therapies for these disoders (e.g. via neuroprosthetic interventions). Concurrently, Anastassiou’ team contributes to multiple other Institute programs.

After completing his undergraduate studies in chemical engineering at ETH Zurich, Anastassiou conducted his Ph.D. in the department of bioengineering at Imperial College London on CNS biosensing methodologies. He then joined Caltech as a postdoctoral fellow where he studied the origin and functionality of extracellular electric fields in brain circuits. Anastassiou has received a number of awards such as the SNSF early and advanced postodoctoral awards, the EPSRC LSI postdoctoral fellowship and the SNSF Professorship award.

Selected Publications View on PUBMED

BioNet: A Python interface to NEURON for modeling large-scale networks

PLOS | ONE
August 2, 2018

Gratiy SL, Billeh YN, Dai K, Mitelut C, Feng D, Gouwens NW, Cain N, Koch C, Anastassiou CA, Arkhipov A

Classification of electrophysiological and morphological types in mouse visual cortex

bioRxiv
July 17, 2018

Gouwens NW, Sorensen SA, Berg J, Lee C, Jarsky T, Ting J, Sunkin S, Feng D, Anastassiou C, Barkan E, Bickley K, Blesie N, Braun T, Brouner K, Budzillo A, Caldejon S, Casper T, Castelli D, Chong P, Crichton K, Cuhaciyan C, Daigle T, Dalley R, Dee N, Desta T, Dingman S, Doperalski A, Dotson N, Egdorf T, Fisher M, de Frates RA, Garren E, Garwood M, Gary A, Gaudreault N, Godfrey K, Gorham M, Gu H, Habel C, Hadley K, Harrington J, Harris J, Henry A, Hill D, Josephsen S, Kebede S, Kim L, Kroll M, Lee B, Lemon T, Liu X, Long B, Mann R, McGraw M, Mihalas S, Mukora A, Murphy GJ, Ng L, Ngo K, Nguyen TN, Nicovich PR, Oldre A, Park D, Parry S, Perkins J, Potekhina L, Reid D, Robertson M, Sandman D, Schroedter M, Slaughterbeck C, Soler-Llavina C, Sulc J, Szafer A, Tasic B, Taskin N, Teeter C, Thatra N, Tung H, Wakeman W, Williams G, Young R, Zhou Z, Farrell C, Peng H, Hawrylycz MJ, Lein E, Ng L, Arkhipov A, Bernard A, Phillips J, Zeng H, Koch C

h-Channels Contribute to Divergent Intrinsic Membrane Properties of Supragranular Pyramidal Neurons in Human versus Mouse Cerebral Cortex

Neuron
November 1, 2018

Kalmbach BE, Buchin A, Long B, Close J, Nandi A, Miller JA, Bakken TE, Hodge RD, Chong P, de Frates R, Dai K, Maltzer Z, Nicovich PR, Keene CD, Silbergeld DL, Gwinn RP, Cobbs C, Ko AL, Ojemann JG, Koch C, Anastassiou CA, Lein ES, Ting JT

From Maxwell's equations to the theory of current-source density analysis

European Journal of Neuroscience
February 8, 2017

Gratiy SL, Halnes G, Denman D, Hawrylycz MJ, Koch C, Einevoll GT, Anastassiou CA

Fully integrated silicon probes for high-density recording of neural activity

Nature
November 8, 2017

Jun JJ, Steinmetz NA, Siegle JH, Denman DJ, Bauza M, Barbarits B, Lee AK, Anastassiou CA, Andrei A, Aydın Ç, Barbic M, Blanche TJ, Bonin V, Couto J, Dutta B, Gratiy SL, Gutnisky DA, Häusser M, Karsh B, Ledochowitsch P, Lopez CM, Mitelut C, Musa S, Okun M, Pachitariu M, Putzeys J, Rich PD, Rossant C, Sun WL, Svoboda K, Carandini M, Harris KD, Koch C5 O'Keefe J, Harris TD

Cell-type- and activity-dependent extracellular correlates of intracellular spiking

Journal of Neurophysiology
May 20, 2015

Anastassiou CA, Perin R, Buzsaki G, Markram H, Koch C

Theta Phase Segregation of Input-Specific Gamma Patterns in Entorhinal-Hippocampal Networks

Neuron
September 24, 2014

Schomburg EW, Fernández-Ruiz A, Mizuseki K, Berényi A, Anastassiou CA, Koch C, Buzsáki G

A biophysically detailed model of neocortical local field potentials predicts the critical role of active membrane currents

Neuron
July 24, 2013

Reimann MW, Anastassiou CA, Perin R, Hill SL, Markram H, Koch C

The origin of extracellular fields and currents — EEG, ECoG, LFP and spikes

Nature Reviews Neuroscience
May 18, 2012

Buzsáki G, Anastassiou CA, Koch C

Ephaptic coupling of cortical neurons

Nature Neuroscience
February 2011

Anastassiou CA, Perin R, Markram H, Koch C

Transcranial electric stimulation entrains cortical neuronal populations in rats

Journal of Neuroscience
August 2010

Ozen S, Sirota A, Belluscio MA, Anastassiou CA, Stark E, Koch C, Buzsáki G