
Anatoly Buchin, Ph.D.
Scientist I
Anatoly Buchin joined the Allen Institute in 2017 and works in Modeling, Analysis and Theory group (MAT). He is currently working on detailed biophysical simulations of individual neurons and networks of human hippocampus. These data-driven simulations are based on combination of electrophysiological and morphological data. The goal of this work is to understand how single cell biophysical properties determine the normal and pathologic dynamics in the human brain. The particular focus of his research are the mechanisms of temporal lobe epilepsy and potential intervention using brain stimulation. Before joining Allen Institute, Anatoly was a post-doc in the lab of Adrienne Fairhall at University of Washington. His research involved analyzing the calcium imaging data of neural net of Hydra vulgaris from Rafael Yuste lab in Columbia University. His graduate research involved data analysis and development of neural network models of epileptic seizures in human temporal lobe epilepsy and modeling of Purkinje cells of cerebellum. He collaborated with Richard Miles group at Brain and Spine Institute in Paris and Michael Häusser lab at University College London. Before that Anatoly was working in Computational Physics Laboratory in Ioffe Institute in St Petersburg, Russia. Anatoly received his PhD in Computational Neuroscience from École Normale Supérieure in Paris, Mphil in Biophysics from St Petersburg Polytechnic University, Mphi in Interdisciplinary Research from Paris Descartes University and BA in Physics from St Petersburg Polytechnic University.

Research
Research Interests
Studying the biophysical mechanisms of a nervous system is a necessary step towards explaining the brain function and behavior. In my research I am focused on the mechanisms of brain dynamics on the single neuron and neural network level. I am interested how single cell properties including morphology and excitability shape the network dynamics and how alterations on the circuit level give rise to various pathologies of the nervous system.
Expertise
- Computational neuroscience
- Single neuron biophysics
- Neural network dynamics
- Dynamical systems
- Numerical simulations
Research Programs
- MAT
Selected Publications View Publications
Multi-modal characterization and simulation of human epileptic circuitry
bioRxiv
May 5, 2020
Buchin A, de Frates R, Nandi A, Mann R, Chong P, Ng L, Miller J, Hodge R, Kalmbach B, Bose S, Rutishauser U, McConoughey S, Lein E, Berg J, Sorensen S, Gwinn R, Koch C, Ting J, Anastassiou CA
bioRxiv
April 2, 2020
Berg J, Sorensen SA, Ting JT, Miller JA, Chartrand T, Buchin A, Bakken TE, Budzillo A, Dee N, Ding SL, Gouwens NW, Hodge RD, Kalmbach B, Lee C, Lee BR, Alfiler L, Zeng H, Koch C, Lein ES, et al.
bioRxiv
April 10, 2020
Nandi A, Chartrand T, Geit WV, Buchin A, Zizhen Yao, Lee SY, Wei Y, Kalmbach B, Lee B, Lein E, Berg J, Sümbül U, Koch C, Tasic B, Anastassiou CA
Adaptation and Inhibition Control Pathological Synchronization in a Model of Focal Epileptic Seizure
eNeuro
September 13, 2018
Buchin A, Kerr CC, Huberfeld G, Miles R, Gutkin B
Neuron
November 1, 2018
Kalmbach BE, Buchin A, Long B, Close J, Nandi A, Miller JA, Bakken TE, Hodge RD, Chong P, de Frates R, Dai K, Maltzer Z, Nicovich PR, Keene CD, Silbergeld DL, Gwinn RP, Cobbs C, Ko AL, Ojemann JG, Koch C, Anastassiou CA, Lein ES, Ting JT
Inverse Stochastic Resonance in Cerebellar Purkinje Cells
PLoS Computational Biology
August 19, 2016
Buchin A, Rieubland S, Häusser M, Gutkin BS, Roth A
Journal of Neuroscience
November 16, 2016
Buchin A, Chizhov A, Huberfeld G, Miles R, Gutkin BS
Optical Memory and Neural Networks
July 10, 2010
Buchin AJ, Chizhov AV