Amanda C. Mitchell, Ph.D.
Amanda joined the Cell Types team at the Allen Institute in 2020. Her work focuses on utilizing single cell epigenomics data towards the creation of cell type specific enhancer viruses to target every cell type in the brain. She received her B.S. in Molecular and Cellular Biology and her Ph.D. in Neuroscience from Vanderbilt University in Nashville, Tennessee. Her graduate dissertation in Karoly Mirnics’s lab explored physical activity transcriptome changes associated with neuroprotection in a MPTP model of Parkinson’s disease. Dr. Mitchell completed a postdoctoral fellowship in Schahram Akbarian’s lab at the Icahn School of Medicine at Mount Sinai, where she studied the role histone modifications and higher dimensional chromatin organization in neuropsychiatric disease and modeled alterations in mice. Prior to joining the Allen Institute, she worked in genetic target identification at Merck for early discovery Neuroscience in the Department of Genetics and Pharmacogenomics. She brings a diverse skillset to the team.
Amanda uses functional genomics, genetics, and epigenetics datasets to identify noncoding regions, genes, cell types, and mechanisms critical for normal brain function & disease and to create novel molecular genetic tools.
- Functional genomics
- Molecular genetic tools
- Molecular genetics
- Cell types
Selected Publications View Publications
September 26, 2019
Liu X, Han D, Somel M, Jiang X, Hu H, Guijarro P, Zhang N, Mitchell AC, Halene T, Ely JJ, Sherwood CC, Hof PR, Qiu Z, Pääbo S, Akbarian S, Khaitovich P
May 5, 2017
Olivia Engmann O, Labonté B, Mitchell A, Bashtrykov P, Calipari ES, Rosenbluh C, Loh YE, Walker DM, Burek D, Hamilton PJ, Issler O, Neve RL, Turecki G, Hurd Y, Chess A, Shen L, Mansuy I, Jeltsch A, Akbarian S, Nestler EJ
January 24, 2017
Mitchell AC, Javidfar B, Pothula V, Ibi D, Shen EY, Peter CJ, Bicks LK, Fehr T, Jiang Y, Brennand KJ, Neve RL, Gonzalez-Maeso J, Akbarian S
September 6, 2016
Mitchell AC, Javidfar B, Bicks LK, Neve R, Garbett K, Lander SS, Mirnics K, Morishita H, Wood MA, Jiang Y, Gaisler-Salomon I, Akbarian S
December 3, 2014
Vogel-Ciernia A, Shen EY, Mitchell AC, Mao W, Whittle C, Dincer A, Jakovcevski M, Pothula V, Rasmussen TP, Giakoumaki SG, Bitsios P, Sherif A, Gardner PD, Ernst P, Akbarian S
November 20, 2014
Roussos P, Mitchell AC, Voloudakis G, Fullard JF, Pothula VM, Tsang J, Stahl EA, Georgakopoulos A, Ruderfer DM, Charney A, Okada Y, Siminovitch KA, Worthington J, Padyukov L, Klareskog L, Gregersen PK, Plenge RM, Raychaudhuri S, Sklar P