Advisor Profiles

Patrick R. Hof, M.D.

Icahn School of Medicine at Mount Sinai

Patrick Hof graduated from the School of Medicine of the University of Geneva, Switzerland, and now is the Irving and Dorothy Regenstreif Research Professor of Neuroscience and the Vice-Chair of the Department of Neuroscience at the Icahn School of Medicine at Mount Sinai in New York. He also leads the Kastor Neurobiology of Aging Laboratories in the Friedman Brain Institute. Dr. Hof became, as of 2012, Editor-in-Chief of the Journal of Comparative Neurology, which was founded by C.L. Herrick in 1891 and is the oldest journal of neuroscience in existence. His laboratory has extensive expertise in the pathology of neuropsychiatric disorders and has established an international reputation in quantitative approaches to neuroanatomy and studies of brain evolution. Dr. Hof's research is directed towards the study of selective neuronal vulnerability in dementing illnesses and aging using classical neuropathologic as well as modern quantitative morphologic methods to determine the cellular features that render the human brain uniquely vulnerable to degenerative disorders, in particular Alzheimer’s disease and frontotemporal dementia. He is an Associate Director of the Alzheimer’s Disease Research Center at Mount Sinai and he receives major funding from the NIA and NIMH. He has been recently funded by Autism Speaks, the Seaver Foundation, and the Simons Foundation for his work on the neuropathology of autism and from the James S. McDonnell Foundation for his studies of brain evolution.