Lucas Cheadle, Ph.D.
Cold Spring Harbor Laboratory
Dr. Lucas Cheadle is an assistant professor of neuroscience at Cold Spring Harbor Laboratory. Originally from the Chickasaw Nation in rural Oklahoma, Dr. Cheadle developed a passion for biomedical research as an undergraduate at Smith College. He later earned a Ph.D. in neuroscience working with Dr. Thomas Biederer at Yale University and completed a postdoctoral fellowship in the laboratory of Dr. Michael Greenberg at Harvard Medical School. Throughout his training, Dr. Cheadle’s work has focused on understanding how neurons in the brain form precise connections with one another. Currently, Dr. Cheadle’s team merges large-scale genomic and transcriptomic approaches such as single-cell RNA-sequencing with functional assays such as high-resolution imaging of neuronal connections in the brains of living mice. Using these approaches, the Cheadle Lab characterizes the contributions of non-neuronal brain cells to the sensory experience-dependent remodeling of neural circuits during postnatal brain development. In the future, they hope to turn these insights into novel therapeutic strategies for treating neurodevelopmental disorders.