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Foundational science fuels breakthroughs

We are leaders in large-scale research that transforms our understanding of human health and disease and shapes how science is conducted worldwide.

We are researching the fundamental components of biology

The more we understand about the function of cells, processes of the brain, and the intricacies of the immune system at a basic, cellular level – the closer we come to treatments and cures for diseases like cancer, COVID-19, and Alzheimer’s.

Our work accelerates discoveries.

Every day our teams work to unlock the mysteries of human biology–how our minds and bodies operate in the world to give life meaning. Amazing new discoveries have been made at the Allen Institute, and when we openly share our data and resources, we allow the global scientific community to make faster progress and new insights into human health.

HEALTH and Disease RESEARCH

Science Programs & Open Data

 

Scientists gathering around performing an experiment together.

Science programs and open science resources

The Allen Institute is comprised of research-focused institutes, groups, and science programs that focus on the fundamental components of biology and bioscience across neuroscience, cell biology, immunology and beyond. Our foundational research accelerates discoveries about health and disease and serves as building blocks for new medicines, medical treatments, and disease prevention.

ABC Atlas of whole mouse brain data

Allen Institute for Brain Science

Characterizing and mapping brain cell types with unprecedented precision and scale.
Colorful image of human cell highlighting key structures

Allen Institute for Cell Science

Understanding human cells holistically and dynamically to predict and understand human health and disease.
Research from an Allen Distinguished Investigator

The Paul G. Allen Frontiers Group

Exploring the frontiers of bioscience and pushing science forward to advance human biology.
Histology image from immunology research

Allen Institute for Immunology

Working to understand the delicate balancing act of the human immune system—how it works when we’re healthy, and what goes wrong in disease.
Colorful scientific image showing neuronal projections across the mouse brain

Allen Institute for Neural Dynamics

Exploring the brain’s activity, at the level of individual neurons and the whole brain, to reveal how we interpret our environments to make decisions.
Abstract colorful image collage of data from the Seattle Hub for Synthetic Biology

The Seattle Hub for Synthetic Biology

Cracking the code of how changes in our genes manifest as changes in health and disease

Exploring the building blocks of life, health, and disease

We focus on foundational science, exploring how the human body functions and is connected at a fundamental level. We delve deep into the mechanics of our brain, probe the structures and functions of our cells, investigate how our bodies fight disease, and pursue ideas that are on the cutting edge of bioscience. We compare healthy cells and immune systems to those affected by diseases like Alzheimer’s, mapping the way forward to new treatments and therapies.

Alzheimer-Brain HPC with axons and plaques zoomed

Alzheimer’s disease

Unlocking the mysteries of this mind-robbing disease affecting more than 55 million people worldwide
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Covid Data

COVID-19

How does the immune system clear COVID-19, and what goes wrong in long COVID?
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Cancer tissue

Cancer

Understanding what goes wrong in the immune system — and how to set it right again
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Allen Institute for Immunology researcher processing samples

Autoimmune disease

What goes wrong when our immune systems attack our own bodies?
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Impact by the numbers

1.5k

Scientists access our resources every day

550k

Each year from more than 200 countries

5k+

Citations of the Allen Mouse Brain Atlas (and counting)

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This large-scale team effort really requires expertise from all different directions.

Meet the people powering our research

You’ll find neuroscientists, cell biologists, mathematicians, physicists, engineers, immunologists, geneticists, informatics experts and a team of administrative professionals working side-by-side to achieve our goals.

Science Programs at Allen Institute